Post-translational mAbs

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Allosteric post-translational modification codes.

Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...

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Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...

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Post-translational regulation of FOXO.

The Forkhead box O (FOXO) family transcription factors play critical roles in a series of cellular processes, including the cell cycle, cell death, metabolism, and oxidative stress resistance. FOXO proteins are subject to several post-translational modifications, which are closely related to their activity. In this paper, we review the post-translational modifications of FOXOs and their biologi...

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ژورنال

عنوان ژورنال: Science-Business eXchange

سال: 2013

ISSN: 1945-3477

DOI: 10.1038/scibx.2013.913